Latest research on Sildenafil

Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

Sildenafil indications

In another randomized, double-blind, placebo-controlled study, the combination of Sildenafil (50 mg before intercourse) with Lidocaine or prilocaine had the same effect, but showed no superiority to placebo (IELT was not considered) (21). [source, 2016]
Sildenafil, which is already used to treat PPHT of the newborn (Noori et al., 2007), was recently shown to effectively inhibit cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 in utero (Luong et al., 2011). [source, 2016]
In the Sildenafil citrate group, only two patients reported the side-effect of headache, which was treated with Paracetamol. [source, 2016]
Therefore, we cannot define the exact mechanism of action of Sildenafil citrate, whether it is due to an increase in sexual intercourse or due to direct effects on the musculature of the distal part of the ureter. [source, 2016]
To best of our knowledge, this is the first RCT evaluating the effect of a PDE5 inhibitor (Sildenafil) as a MET. [source, 2016]
There were no serious complications in the patients on Sildenafil citrate during the study period and only two patients in the Sildenafil citrate reported the side-effect of headache, which was treated with Analgesic. [source, 2016]
In conclusion, in the present randomised double-blind placebo-controlled study, a PDE5 inhibitor (Sildenafil citrate) was a safe and effective MET for DUS of 5–10 mm. [source, 2016]
Sildenafil may exert its effect indirectly. [source, 2015]
The balance of Bax and Bcl-2 plays an important role in the process of apoptosis, we therefore examined the effect of Sildenafil on Bax and Bcl-2 expression. [source, 2015]
Bcl-2/Bax was decreased in myocardium and this decrease was significantly reversed by treatment with Sildenafil, suggesting that Sildenafil exerted the anti-apoptotic effect by up-regulation Bcl-2/Bax radio than vehicle-treated pigs (p < 0.05, Figure 2a, b). [source, 2015]