Latest research on Sildenafil

Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

Sildenafil interactions

In these analyses, medication costs were assessed and include any of the eight groups of prescription medications used to possibly treat IPF (corticosteroids, Azathioprine, Cyclophosphamide, N-acetylcysteine, Sildenafil, interferon-gamma, bosentan, etanercept). [source, 2016]
He is maintained on Sildenafil (20 mg three times daily), bosentan (62.5 mg twice daily), Treprostinil (121 ng/kg/min subcutaneously), and Warfarin (3 mg daily). [source, 2016]
Pharmacologic therapy may include selective serotonin reuptake inhibitor (SSRI) therapy (Citalopram, Sertraline, fluoxetine, dapoxetine or Paroxetine), phosphodiesterase type 5 (PDE5) inhibitor therapy (tadalafil or Sildenafil), topical desensitizing agents (prilocaine or Lidocaine) and other agents (Tramadol or Pindolol). [source, 2016]
In another randomized, double-blind, placebo-controlled study, the combination of Sildenafil (50 mg before intercourse) with Lidocaine or prilocaine had the same effect, but showed no superiority to placebo (IELT was not considered) (21). [source, 2016]
Sildenafil, Clomipramine, Sertraline, Paroxetine and the pause-squeeze technique improved the baseline IELT from 1 minute to 15 minutes, 4 minutes, 3 minutes, 4 minutes and 3 minutes, respectively (22). [source, 2016]
In contrast to Paroxetine alone, Sildenafil plus Paroxetine improved IELT and satisfaction (23). [source, 2016]
Sildenafil plus Sertraline, in comparison to Sertraline alone, significantly improved IELT and satisfaction (24). [source, 2016]
The combination of Sildenafil with Paroxetine and psychological and behavioral counseling in patients who had failed with other treatments considerably improved IELT and satisfaction (25). [source, 2016]
Nineteen patients were treated with a prostacyclin PGI2 analog (beraprost sodium), while four patients were treated with an endothelin receptor antagonist (bosentan) or a phosphodiesterase type V inhibitor (Sildenafil). [source, 2016]
Inhaled Nitric oxide, oral Sildenafil or Bosentan were used to manage pulmonary hypertensive crisis. [source, 2016]