Latest research on Sonata

Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Zaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States.

Latest findings

Several pharmacological therapies for insomnia have been formulated, including benzodiazepine receptor antagonists (BzRAs) (eg, benzodiazepines and nonbenzodiazepine sedative-hypnotics, such as Zolpidem, Zaleplon, and Eszopiclone), Melatonin, Melatonin-receptor agonists, and various antidepressant medications including Quetiapine, Amitriptyline, Mirtazapine, and Trazodone. [source, 2016]
However, if pharmacological therapy is indicated, the current AASM guidelines recommend nonbenzodiazepine hypnotics (ie, Zolpidem, Zaleplon, Eszopiclone) or Melatonin MT1 and MT2 receptor agonists (ie, ramelteon) as first-line agents, followed by sedating antidepressants and benzodiazepines for patients failing first-line therapies. [source, 2016]
Three TM patients with AHH underwent pituitary MRI using a 1.5T scanner (Sonata, Siemens Medical, Erlanger, Germany). [source, 2016]
All data was acquired on a single 1.5T Siemens Sonata MRI scanner. [source, 2016]
Imaging data were collected using either a Siemens 1.5 T Sonata scanner, or a Siemens 3 T Trio scanner. [source, 2016]
The exposure included benzodiazepines and non-benzodiazepine hypnotics that bind to the gamma-aminobutyric acid (GABA) receptor, such as Zolpidem, Zaleplon, and Eszopiclone. [source, 2016]
For each measurement, the ICCs in Signa Excite and Verio were generally in better agreement compared with the results from Sonata and TrioTim. [source, 2016]
The mean and standard deviation of the ICC for each MRI model were 0.85 ± 0.16 (Signa Excite), 0.68 ± 0.34 (Sonata), 0.66 ± 0.33 (TrioTim), and 0.87 ± 0.17 (Verio). [source, 2016]
While the vast majority of ICCs for each label from repeat scans were high in scans from the Signa Excite and Verio MRI scanners, a certain portion of low ICCs were noted in the Sonata and TrioTim models. [source, 2016]
Although both Signa Excite (GE) and Sonata (Siemens) are 1.5T MRI models, the agreement and variance in generated FreeSurfer results were quite different between models. [source, 2016]