Latest research on Sulfasalazine

A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)

Latest findings

Salazar Andres (Oncovir, Washington, DC, USA). [source, 2016]
The drugs of choice for the treatment of IBD are 5-aminosalicylic acid and Sulfasalazine. [source, 2016]
They are composed of cranial neural crest-derived mesenchymal cells and mesoderm-derived endothelial cells, which together are covered by pharyngeal ectoderm-derived epithelial cells (Iwata et al., 2011; Hill et al., 2015). [source, 2016]
One study has shown changes in lipid metabolism in mice with aberrant TGF-β signaling contribute to cleft palate formation, indicating a potential mechanistic link between diabetes mellitus and cleft palate (Iwata et al., 2014). [source, 2016]
Regarding functional expression, HEK293 cells heterologously expressing TRPV1, TRPC1, TRPM2, or TRPM7 responded well to H2O2, in agreement with previous reports (Hara et al., 2002; Aarts et al., 2003; Yoshida et al., 2006; Salazar et al., 2008), and as well to APAP as indicated by increased Ca2+ entry. [source, 2016]
Iwata et al studied children born very preterm and published two studies on DEHSI in relation to outcomes at school age [13, 14]. [source, 2016]
Since Blakeslee published the classical work on Datura trisomics, trisomy had been widely reported in plants, such as in tomato (Lesley, 1932; Rick and Barton, 1954; Hagemann, 1969) and rice (Iwata and Omura, 1984; Khush ; Wu ). [source, 2016]
In accordance with our results, Salazar et al. investigated alterations in the choroid in hypercholesterolemic rabbits and concluded that the choroid was thicker in the presence of hypercholesterolemia [28]. [source, 2016]
Background fluorescence, measured in region of sample without cells, was subtracted from fluorescence values (Salazar et al., 2008). [source, 2016]
Analogous to the acrylate systems investigated by both Iwata [41] and Bowman [42], described above, GOx was used to oxidize and reduce glucose and Oxygen to gluconolactone and hydrogen peroxide, respectively; the hydrogen peroxide was then converted to hydroxyl radicals through the Fenton reaction involving Fe2+. [source, 2016]