Latest research on TNF-R2

Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids

Latest findings

In addition to the modifying effect of TFAs on the lipid profile, dietary intake of TFAs has been associated with an increase in markers of endothelial dysfunction such as CRP, interleukin-6, soluble Tumor necrosis factor receptor 2, E-selectin and soluble cell adhesion molecules [7]. [source, 2016]
Biologic agents were mainly in decreasing order of frequency: etanercept (Enbrel), adalimumab (Humira), abatacept (Orencia), rituximab (MabThera), and tocilizumab (Actemra). [source, 2016]
Moreover, the influence of different concentration of TNF-α mediated by Enbrel (Etanercept), which is a genetically engineered fusion protein that can bind and inactivate TNF-α [22], on CCl4-induced acute liver injury remains largely unknown. [source, 2016]
To investigate the effects of TNF-α on acute liver injury, different doses of Enbrel were pretreated 15 min before CCl4 administered. [source, 2016]
The ALT and AST levels were all decreased pre-treated with Enbrel of 0.25, 0.5 and 1 mg/kg when the serum TNF-α was slightly blocked (Fig. 1c) in CCl4-induced liver injured rats (Fig. 1a, b). [source, 2016]
Our data suggested ALT had 62 % reduction and AST had 33 % reduction as Enbrel was added from 0 to1 mg/kg. [source, 2016]
However, as TNF-α was sequentially blocked at high dose of Enbrel (4 and 8 mg/kg), the ALT and AST levels were increased instead and reached the maximum at 8 mg/kg Enbrel when litter serum TNF-α was detected (Fig. 1c). [source, 2016]
However, interestingly, the serum ALT and AST were less at 0 mg/kg Enbrel used than 8 mg/kg Enbrel. [source, 2016]
It indicated that the extent of hepatocellular damage were slighter at high level of TNF-α (0 mg/kg Enbrel) than very low level of TNF-α (8 mg/kg Enbrel). [source, 2016]
Furthermore, Hematoxylin and Eosin (HE) staining results also showed that the hepatocellular steatosis was serious at 0 or 8 mg/kg Enbrel, especially more serious at 8 mg/kg Enbrel used in CCl4-induced acute injury rats (Fig. 1d). [source, 2016]