Latest research on TNF-R2

Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids

TNF-R2 indications

In addition to the modifying effect of TFAs on the lipid profile, dietary intake of TFAs has been associated with an increase in markers of endothelial dysfunction such as CRP, interleukin-6, soluble Tumor necrosis factor receptor 2, E-selectin and soluble cell adhesion molecules [7]. [source, 2016]
To investigate the effects of TNF-α on acute liver injury, different doses of Enbrel were pretreated 15 min before CCl4 administered. [source, 2016]
Moreover, the protective effect seemed more prominent than the damaging effect at 0 mg/kg Enbrel. [source, 2016]
We speculated that the declined speed of damaging effect of TNF-α was faster than the protective effect during the process of persistently increasing Enbrel in the CCl4-induced acute liver injury. [source, 2016]
After Enbrel was increased gradually from 0 to 1 mg/kg, TNF-α were decreased (Fig. 1c), and its damaging effect had been receded as well as the protective effect. [source, 2016]
Relatively, the protective effect was prominent at the maximum when Enbrel was added at 1 mg/kg, which leaded to alleviate the whole extent of liver injury. [source, 2016]
As Enbrel was continually added from 1 to 8 mg/kg, the damaging effect and the protective effect of TNF-α were further receded. [source, 2016]
Thus, its protective effect and damaging effect were declined to the maximum and were almost abolished at 8 mg/kg Enbrel. [source, 2016]
However, how did TNF-α and inflammatory factors exert the protective effect in the process of increasing Enbrel in the acute liver injury? [source, 2016]
It indicated that NF-κB played a significantly role and its effect was gradually declined as well as anti-apoptotic genes, when the concentration of TNF-α was blocked by Enbrel in the CCl4-induced acute liver injury. [source, 2016]