Latest research on TNF-R2

Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids

TNF-R2 side effects

In addition to the modifying effect of TFAs on the lipid profile, dietary intake of TFAs has been associated with an increase in markers of endothelial dysfunction such as CRP, interleukin-6, soluble Tumor necrosis factor receptor 2, E-selectin and soluble cell adhesion molecules [7]. [source, 2016]
The ALT and AST levels were all decreased pre-treated with Enbrel of 0.25, 0.5 and 1 mg/kg when the serum TNF-α was slightly blocked (Fig. 1c) in CCl4-induced liver injured rats (Fig. 1a, b). [source, 2016]
However, as TNF-α was sequentially blocked at high dose of Enbrel (4 and 8 mg/kg), the ALT and AST levels were increased instead and reached the maximum at 8 mg/kg Enbrel when litter serum TNF-α was detected (Fig. 1c). [source, 2016]
However, after the treatment of CCl4, high level of TNF-α was obviously increased as well as hepatocellular apoptosis at 0 mg/kg Enbrel. [source, 2016]
Meanwhile, as Enbrel was increased to 1 mg/kg, the apoptosis were significantly decreased. [source, 2016]
However, in CCl4-induced rats, the expression of IL-6, IL-8, IL-β and IFN-γ were decreased as the concentration of TNF-α was blocked by increased dose of Enbrel, (Fig. 3a–d) while IL-4 had a completely opposite outcome (Fig. 3e). [source, 2016]
Western-blotting and RT-PCR results showed that the expression of anti-apoptosis genes were declined as TNF-α was blocked by increased Enbrel (Fig. 4b, c). [source, 2016]
For the damaging side, our results suggested that serum ALT and AST were decreased (Fig. 1a, b), as the Enbrel was added from 0 to 1 mg/kg in acute liver injury. [source, 2016]
Interestingly, in our working, we found that the change of liver function presented an obvious “V” shape in the whole process of persistently increased Enbrel. [source, 2016]
After Enbrel was increased gradually from 0 to 1 mg/kg, TNF-α were decreased (Fig. 1c), and its damaging effect had been receded as well as the protective effect. [source, 2016]