Latest research on TYROSINE

A non-essential amino acid. In animals it is synthesized from phenylalanine. It is also the precursor of epinephrine; thyroid hormones; and melanin. [PubChem]

Latest findings

Examples include monoamine oxidase B [MAOB] [22], the Dopamine D4 receptor [DRD4] [23], the Dopamine transporter [SLC6A3] [24], TYROSINE hydroxylase [TH] [25] and Dopamine beta-hydroxylase [DHB] [25]. [source, 2016]
Several members of the Rho GTPases have been shown to be regulated by serine, Threonine or TYROSINE phosphorylation. [source, 2016]
The biological effects of neurotrophins are mediated via two major receptors, TYROSINE kinase (Trk) receptors and 75 kDa (p75NTR). [source, 2016]
We identified whether the review focused on one specific treatment explicitly (alone or combined with other treatments), lumped different treatments of the same type together (e.g., monochemotherapy or targeted therapy), and lumped different types of treatments together (e.g., monochemotherapy and EGFR TYROSINE kinase inhibitors considered the same intervention). [source, 2016]
In addition, Cdc42 is phosphorylated on TYROSINE 64 (64Y) by SRC TYROSINE kinase, and this phosphorylation results in the increased interaction between Cdc42 and GDI [17]. [source, 2016]
In our example, Erlotinib and Gefitinib were frequently lumped together in EGFR TYROSINE kinase inhibitors and Docetaxel and Pemetrexed were lumped together in monochemotherapy. [source, 2016]
A gain-of-function point mutation has been reported in the Janus 2 TYROSINE kinase (JAK2) gene, which increases JAK2 kinase activity and has the potential to affect clinical outcomes 1-2. [source, 2016]
Furthermore, the IGF-1 receptor (IGF-1R), a transmembrane TYROSINE kinase, is frequently upregulated in BC [10, 11]. [source, 2016]
Another gene we identify is TH, which encodes TYROSINE hydroxylase, the rate-limiting enzyme in the synthesis of Dopamine and Noradrenaline [66]. [source, 2016]
Tyrosine hydroxylase catalyzes the conversion of L-Tyrosine into L-DOPA. [source, 2016]