Latest research on Tamsulosin

Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.

Latest findings

In the present study, we aimed to compare the safety and efficacy of Tamsulosin, Alfuzosin and their combinations with Methylprednisolone in the medical management of lower ureteric stones. [source, 2016]
Group I patients received Tamsulosin 0.4 mg daily and those in Group II received Tamsulosin 0.4 mg and Methylprednisolone 8 mg daily. [source, 2016]
In a randomised double-blind study, Al-Ansari et al. [14] studied the efficacy of Tamsulosin in 100 patients and reported an 82% stone expulsion rate vs 61% in the control group (P = 0.02). [source, 2016]
Kaneko et al. [15] reported a 77% stone expulsion rate after using low-dose Tamsulosin. [source, 2016]
Although Tamsulosin has been extensively studied for MET, other α-blockers have also shown great efficacy. [source, 2016]
In our present study, we have comparable results with Tamsulosin (54.7%) and Alfuzosin (52.8%). [source, 2016]
Porpiglia et al. [2] studied the combined effect of corticosteroid and Tamsulosin in MET in 114 patients. [source, 2016]
They reported an 84.8% stone expulsion rate in the combination arm (deflazacort and Tamsulosin). [source, 2016]
Conversely, Dellabella et al. [17] found no statistically significant difference in the stone expulsion rate when they compared Tamsulosin alone to its combination with steroids (P = 0.612). [source, 2016]
In our present study, we found a significant increase in the stone expulsion rate when using the combination of Methylprednisolone and Tamsulosin compared with Tamsulosin alone, with no significant difference for the time to stone expulsion. [source, 2016]