Latest research on Tenofovir

Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name Viread®, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. [Wikipedia] In vivo tenofovir disoproxil fumarate is converted to tenofovir, an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5'-monophosphate.

Tenofovir indications

Especially in those with decompensated liver disease, undergoing immunosuppressive treatment or with contraindications, and those unwilling to receive Peg-IFN, Entecavir or Tenofovir is the only therapeutic options in patients [4]. [source, 2016]
While adherence <95% increased the risk of virologic failure (aHR, 1.28; 95% CI, 1.07–1.54), the inclusion of adherence in the Cox model had no notable effect on the HR or CI of the remaining covariates (Tenofovir group aHR, 1.48; 95% CI, 1.21–1.80). [source, 2016]
The effect of regimen on time to virologic failure was consistent between the primary and time-updated models and reflected a 47% increase in the risk of virologic failure for patients in the Tenofovir group (aHR, 1.47; 95% CI, 1.24–1.75). [source, 2016]
Our results are consistent with those from other evaluations of outcomes among patients who received ART containing Nevirapine and Tenofovir, thus supporting the belief that NNRTI effectiveness differs by NRTI selection. [source, 2016]
Given access to all available drugs, more than three-quarters of doctors would use the WHO recommended first line fixed dose combination of Tenofovir (TDF), Emtricitabine (or the equivalent analogue, Lamivudine) and Efavirenz (EFV) for themselves, suggesting high confidence in the efficacy and side effect profile of the combination. [source, 2016]
Moreover, drug interactions with other nucleoside analogs have been well studied: e.g. Tenofovir disoproxil fumarate, when used alone or in combination with Emtricitabine effectively prevents HIV-1 infection in antiretroviral pre-exposure prophylaxis (PrEP) [29]. [source, 2016]
For validation purposes, a simulation study was set up to investigate the effectiveness of once daily treatment with rilpivirine 25mg (RPV), Emtricitabine 200mg (FTC) and Tenofovir DF 245mg (TDF) as initial ART, mimicking the conditions and population of the STaR study [5, 33]. [source, 2016]
In this regard, no evidence of proximal tubulopathy (Tenofovir) or characteristic urine or kidney tissue crystals (Indinavir, atazanavir) were observed and toxic effects of hematuria may account for tubular injury features observed in the biopsy [8]. [source, 2016]
We excluded participants with acute viral illness possibly due to HIV seroconversion, any contraindication to Tenofovir disoproxil fumarate or Emtricitabine, and those being treated with or with treatment indicated for hepatitis B infection. [source, 2016]
An economic assessment28 based on a mathematical model adapted to the UK epidemic in men who have sex with men suggests that providing targeted PrEP to this group from 2016 would be cost-effective at current prices, or without targeted implementation if Tenofovir disoproxil fumarate–emtricitabine was halved in price. [source, 2016]