Latest research on Tramadol

A narcotic analgesic proposed for moderate to severe pain. It may be habituating. [PubChem] Tramadol is also prepared as a variable release capsules, marketed under the brand name ConZip. For example, a 150 mg capsule will contain 37.5 mg of the immediate release form and 112.5 mg of the extended release form.

Latest findings

Postoperative analgesia was ensured by intravenous Paracetamol (1 g/6 h) completed by intravenous Tramadol 100 mg/8 h) if necessary. [source, 2016]
After adjusting for the number of medications (prescription and non-prescription) a driver was taking during each case and control period (Table 4), individuals (N = 11) who were taking Tramadol (OR = 11.41; 95 % CI 1.27, 102.15) were at a significantly increased risk of motor vehicle collision while taking this substance during the risk period compared to control periods. [source, 2016]
Second, despite small sample sizes, those taking Tramadol (N = 11) were at a significantly increased risk of motor vehicle collision if they took this substance 14 days prior to collision compared to control times. [source, 2016]
As for the risk of motor vehicle collision posed by individual medications, two previous studies have investigated the risk of motor vehicle collision associated with the use of Tramadol [29, 30]. [source, 2016]
In the study by Bachs et al., Tramadol use was not significantly associated with an increased risk of motor vehicle collision among a Norwegian cohort of adult drivers aged 18–70 years, though it was trending in the direction of increased risk (Risk 1.5; 95 % CI 0.9, 2.3). [source, 2016]
In the study by Gibson et al., Tramadol was significantly associated with an increased risk of collision (Risk 9.17; 95 % CI 7.81, 10.77) in an English cohort of drivers aged 18–74 years. [source, 2016]
At high doses, Tramadol is also known to affect balance [31]. [source, 2016]
Therefore, the effects of Tramadol are likely not age-dependent because this analysis was limited to older adult drivers whereas other studies investigated drivers less than 74 years of age and the results were comparable. [source, 2016]
Those taking frequently prescribed medications, such as Tramadol, were at a significantly increased risk of motor vehicle collision while taking these substances during the 14 day risk period compared to control periods. [source, 2016]
The time of the first request for rescue analgesia was noted and rescue analgesia was provided with injection Tramadol 1 mg/kg i.v. on demand or when VAS score more than 5 whichever was earlier. [source, 2016]