It is believed that EAC represents a cutaneous manifestation of a type IV hypersensitivity reaction to different causes and underlying systemic diseases, including: food Allergy
, arthropod bites, drug reactions (Finasteride
, etizolam, cimetidine, penicillin, salicylates, Spironolactone
, Gold sodium thiomalate
, rituximab), infections disease (bacterial, viral, parasitic, fungal, mycobacterial), endocrine and immunological disorders (menstrual cycle, Graves disease, Hashimoto thyroiditis, Sjögren syndrome, autoimmune progesterone dermatitis), hematological and other neoplastic disorders (Hodgkin lymphoma, non-Hodgkin lymphoma, acute leukemia, histiocytosis, multiple myeloma, nasopharyngeal carcinoma, prostatic adenocarcinoma, breast carcinoma, ovarian carcinoma) [5–10].