Latest research on Vardenafil

Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). The most abundant PDE in the human corpus cavernosum is the cGMPspecific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP.

Latest findings

Other PDE5 inhibitors (tadalafil and Vardenafil) have limited data on their effect in PE (19, 27). [source, 2016]
In studies conducted to evaluate three PDE5 inhibitors (Sildenafil, Vardenafil, and tadalafil) it was found that PDE5 inhibitors could reverse the tension of isolated human ureteric smooth muscles via cGMP-mediated pathways [9]. [source, 2016]
The lack of sufficient deterrent effect is also supported by our findings that many companies were repeat offenders and that companies on numerous occasions ignored rulings as evidenced by subsequent rulings of failures to comply with undertakings (see Levitra example in Table 5 for a particularly illustrative case). [source, 2015]
Oral phosphodiesterase type 5 (PDE5) inhibitors including avanafil, Sildenafil, tadalafil, and Vardenafil are proven to be safe and effective for managing ED [6–14]. [source, 2015]
At M24, 28 patients (37.3%) were using PDE5i (Sildenafil, tadalafil or Vardenafil), and two patients were using a vacuum in association with IAI. [source, 2015]
Similarly, Vardenafil mimics the effect of NO by increasing GMPc levels with a subsequent reduction of histamine release and mast-cell-mediated allergic reactions [54]. [source, 2015]
These authors showed that treatment with tadalafil or Vardenafil suppressed IL-8 and IP-10 secretion induced by inflammatory (TNF-α) and metabolic (oxLDL, AGE and IGF-1) stimuli. [source, 2015]
Phosphodiesterase-5 (PDE-5) inhibitors (Sildenafil, tadalafil, and Vardenafil) are currently applied for clinical use in nonmalignant diseases (e.g., pulmonary hypertension). [source, 2015]
Men commonly turn to PDE5 inhibitors to assist with ED, with Sildenafil, tadalafil, and Vardenafil as the commonly used drugs in this class. [source, 2015]
Vardenafil and Sildenafil have a shorter duration of action, with a half-life of about 4 h, while the longer-acting tadalafil has a half-life of 17.5 h. [source, 2015]