Latest research on Velcade

Bortezomib (originally PS-341 and marketed as Velcade by Millennium Pharmaceuticals) is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.

Velcade interactions

She was treated with Revlimid, Velcade, and Dexamethasone beginning in February 2013. [source, 2016]
He was also treated with Velcade, Dexamethasone, and Revlimid before undergoing autologous stem cell transplant in February 2014. [source, 2016]
In our patient, her donor-derived multiple myeloma was treated with Velcade, Revlimid, and Dexamethasone followed by autologous stem cell transplantation. [source, 2016]
There are ∼86,000 new cases of MM occurring worldwide each year, with MM accounting for an estimated 11,090 deaths in the US in 2014 and an estimated 10,390 deaths in Europe in 2012.4 The introduction of the novel agents, including proteasome inhibitors (PIs) (bortezomib – Velcade and carfilzomib – Kyprolis) and immunomodulatory drugs (Thalidomide – Thalomid, lenalidomide – Revlimid, and pomalidomide – Pomalyst), was an important advance in the therapy of MM. [source, 2016]
To determine if Dna2 and Sae2 are substrates of proteasomal degradation following Caffeine treatment, we repeated the time-courses in the presence of proteasome inhibitor PS-341 (75). [source, 2015]
Ten min after PS-341 addition (55 min after HO induction), 20 mM Caffeine was added to the medium. [source, 2015]
Treatment with PS-341 prior to Caffeine treatment stabilized Sae2 levels when compared to cells not treated with the proteasome inhibitor (Figure 4A). [source, 2015]
Dna2 was partially stabilized in pdr5Δ rpn4Δ even without addition of PS-341 (compare Figure 4B with Figure 3B), but completely stabilized when the cells were treated with PS-341 prior to Caffeine treatment. [source, 2015]
Last, we show that inhibition of proteasomal degradation by PS-341 treatment stabilizes Sae2 levels in cells and prevents the reduction of resection following Caffeine treatment. [source, 2015]
Three months later, she developed disease progression and was treated with 4 cycles of bortezomib and Velcade and low dose Dexamethasone. [source, 2015]