Latest research on Viracept

A potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. [PubChem]

Latest findings

Successful cases of structure-based virtual screening include Gleevec targeting a TYROSINE kinase [10], Agenerase and Viracept for HIV protease [11]. [source, 2015]
De rares cas d´atteinte nerveuse périphérique ont été attribués au saquinavir (lnvirase), ainsi qu´un risque d´aggravation d'une neuropathie préexistante sous nelfinavir (Viracept) [2, 4]. [source, 2015]
In March 1997, the United States Food and Drug Administration (FDA) approved Nelvinavir (NFV, brand name Viracept) for HIV treatment in humans [source, 2015]
Nelfinavir (brand name: Viracept) was developed by Agouron Pharmaceuticals (Pfizer, Inc., New York, NY, USA) and approved in 1997. [source, 2015]
Metformin (VWR, cat# 89147-892), Chloroquine phosphate (Fisher Scientific, ICN19391910), Rapamycin (LC Labs, cat# R-5000), Dasatinib (LC Labs, cat# D-3307), and nelfinavir mesylate (Creative Dynamics Inc, special order except in syngeneic mouse model, which used pulverized Viracept tablets obtained from the Moores Cancer Center pharmacy) were purchased in powdered form. [source, 2015]
14 days after injection, the control group received daily (7x/week) vehicle gavage injections (50% PEG400), the CN group received daily gavages of Chloroquine (30 mg/kg) and nelfinavir (250 mg/kg, from pulverized Viracept tablets) in 50% PEG400, and the Necramed group received daily gavages of Chloroquine (30 mg/kg), nelfinavir (250 mg/kg), Rapamycin (2.24 mg/kg), Metformin (150 mg/kg), and Dasatinib (4 mg/kg) in 50% PEG400. [source, 2015]
Nelfinavir (Viracept) is an FDA approved HIV protease inhibitor identified through structure-based design with a low nanomolar inhibitory concentration against the HIV aspartyl protease (Kaldor et al., 1997 ▸). [source, 2015]
In 1996 protease inhibitors were approved for treatment of patients with HIV and currently include saquinavir (Fortovase), Saquinavir Mesylate (Invirase), ritonavir (Norvir), amprenavir (Agenerase), lopinavir (Kaletra), Indinavir sulfate (Crixivan), nelfinavir mesylate (Viracept), and atazanavir sulfate (Reyataz). [source, 2014]
The most commonly cited are the human immunodeficiency virus (HIV) drugs, such as amprenavir (Agenerase) and nelfinavir (Viracept), which were developed using the crystal structure of HIV protease [14]. [source, 2013]
This latter group includes bortezomib (Velcade), celecoxib (Celebrex), and nelfinavir (Viracept) (see the following). [source, 2012]