Latest research on Xolair

A recombinant DNA-derived humanized IgG1k monoclonal antibody that selectively binds to human immunoglobulin E (IgE). Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin.

Latest findings

Through our systematic analyses, which included the test set and the validation set, the 4 proteins (among the proteins that were consistently identified) that were most overexpressed in the post-Tx samples in comparison to the pre-Tx samples were serum albumin (ALBU), lumican (LUM), Ig kappa chain C region (IGKC), and Ig gamma-1 chain C region (IGHG1). [source, 2016]
Using nano liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS), we found statistically significant differences in several salivary proteins, including elevated prolactin-inducible protein, lactotransferrin, Ig kappa chain C region, Ig gamma-1 chain C region, Ig lambda-2 chain C regions, neutrophil elastase, polymeric immunoglobulin receptor and deleted in malignant brain tumours 1. [source, 2015]
Increases in these proteins correspond with our prior observations confirming statistically significant increases in proteins with similar function, Ig kappa chain C region, Ig gamma-1 chain C region and Ig lambda-2 chain C regions 34. [source, 2015]
Immunoglobulin chains were combined into the following proteins, representing the abundant proteins from the group: Ig gamma-1 chain C region (comprising of lambda, gamma and kappa and heavy chains), Ig alpha-1 chain C region (comprising of Ig alpha chains and J chain) and Ig mu chain C region. [source, 2015]
While there are no reports of fatal anaphylaxis as a result of Xolair, some cases have been serious and potentially life-threatening. [source, 2015]
Therefore, the FDA requires that people receiving Xolair be monitored in the physician's office for a period of time after their injections. [source, 2015]
Also, it is not yet known what the potential long term effects of Xolair use may have on people who are prone to getting cancer (such as the elderly). [source, 2015]
While it would appear that Xolair has potentially severe side effects, it must be remembered that anaphylaxis and cancer formation occurred only in a very small number of patients. [source, 2015]
The study protocol (Identifying Responders to Xolair (Omalizumab) Using Eosinophilic Esophagitis as a Disease Model, ClinicalTrials.gov Identifier: NCT01040598) was designed, written, edited, and the data were stored and analyzed, by employees of the sponsor, O&O ALPAN, LLC (S1 Protocol). [source, 2015]
Xolair is a sterile, white, preservative-free lyophilized powder that is reconstituted with water for injections and administered as an SC injection. [source, 2015]