Latest research on Xolair

A recombinant DNA-derived humanized IgG1k monoclonal antibody that selectively binds to human immunoglobulin E (IgE). Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin.

Xolair interactions

Tysabri (Natalizumab, Biogen Idec and Elan, LotA: 080475); Vectibix (Panitumumab, Amgen, Ch.B.: 1023731); and Xolair (Omalizumab, Genentech/Novartis, Ch.B. [source, 2014]
This is a typical formulation currently used for other monoclonals, such as Herceptin, Xolair, Raptiva, and Avastin. [source, 2013]
Abciximab (Reopro) and Omalizumab (Xolair) were purchased from Eli Lilly (Switzerland). [source, 2013]
As it should be expected, proteins related to immune response as Ig gamma-1 chain C region, Ig gamma-3 chain C region, lactoferroxin-C, lactrotransferrin, leukocyte elastase inhibitor, apolipoprotein E, alpha 1 antitrypsin, annexin, cathelicidin Antimicrobial peptide, cathepsin G, coronin-1A, dermcidin isoform 2, heat shock protein beta-1, myeloperoxidase, neutrophil defensin 3, S100 A8, and S100 A9 were present in samples from deep pockets and/or have elevated relative abundance compared to samples from healthy sites (Table 3). [source, 2013]
Among spots expressed differently between groups, there were modulators of immune responses (such as polymeric immunoglobulin receptor (PIGR), immunoglobulin light chain, Ig alpha-1 chain C region, PLSL, Ig gamma-1 chain C region, IgG K chain), proteins implicated in antioxidant defence (thioredoxin (THIO), albumin (ALBU), ceruloplasmin (CERU), Glutathione peroxidase 3 (GPX3)), cell-cycle regulators (creatinine kinase B-Type, ADP ribosylation factor-like protein 3 and annexin A3 (ANXA3)), proteins involved in ion transport (such as serotransferrin (TRFE) and hemoglobin subunit beta) and several inflammatory proteins (including pigment epithelium derived factor (PEDF) and apolipoprotein A1 (APOA1)). [source, 2011]
First, the immunoglobulin-related proteins Ig gamma-1 chain C region (IGHG1), Ig alpha-2 chain C region (IGHA2), Ig kappa chain V-III region VG (KV309), and polymeric immunoglobulin receptor (PIGR) all showed a similar pattern of lower expression in the proximal colon compared to the distal colon (Fig. 7a and b). [source, 2011]
These proteins include 70‚ÄČkDa lysosomal Alpha-glucosidase (GAA), Apolipoprotein D (APOD), Alpha-2-HS-glycoprotein chain B (FETUA), Alpha-1-acid glycoprotein 1 (ORM1), Antithrombin-III (SERPINC1), Beta-galactosidase (GLB1), Ceruloplasmin (CP), Cubilin (CUBN), Epidermal growth factor (EGF), Epididymis secretory sperm binding protein Li 44a (E9KL23), Galectin-3-binding protein (LGALS3BP), Golgi phosphoprotein 2 (GOLPH2), Haptoglobin beta chain (HP), Ig gamma-1 chain C region (IGHG1), Ig gamma-2 chain C region (IGHG2), Kininogen 1 (KNG1), Leucine-rich alpha-2-glycoprotein (LRG), Plasma protease C1 inhibitor (SERPING1), Prostaglandin D2 synthase 21‚ÄČkDa (PTGDS), Transferrin (TF), Trypstatin (AMBP), Uromodulin (UMOD), and Zinc-alpha-2-glycoprotein (AZGP1). [source, 2011]