Latest research on d-amphetamine

Dextroamphetamine is the dextrorotary stereoisomer of the amphetamine molecule, which can take two different forms. It is a slightly polar, weak base and is lipophilic.

Latest findings

For systemic drug administration, mice were treated intraperitoneally (i.p.) with 10 mg/kg shield1 (Clontech Laboratories, Saint-Germain-en-Laye, France; Cheminpharma, Branford, U.S.), 2.5 mg/kg d-amphetamine sulfate (Sigma Aldrich, Germany) dissolved in sterile saline with a volume of 0.1 ml/10 g. [source, 2016]
In a blinded randomized, placebo-controlled, parallel-group study, Weiss et al89 compared individual cognitive behavioral therapy (CBT) and Dexedrine (CBT/DEX) with CBT and placebo (CBT/PLB) in a sample with age ranging between 18 and 66 years. [source, 2016]
After 1 year, 85% of patients were on Methylphenidate (mean: 25.5±8.7 mg/day; 0.87±0.34 mg/kg/day) and 15% on dexamphetamine (mean: 10.4±4.8 mg/day; 0.30±0.15 mg/kg/day), with 31% taking the same dose every day and 58% taking medication on school days but less often or not at all on nonschool days. [source, 2016]
After 3 years, 93% were on Methylphenidate (mean: 35.2±16.3 mg/day; 1.00±0.45 mg/kg/day) and 7% on dexamphetamine (mean: 10.0±2.5 mg/day; 0.34±0.08 mg/kg/day); 42% took the same dose every day and 51% took medication on school days but less often or not at all on nonschool days. [source, 2016]
The main reason for changing from dexamphetamine to Methylphenidate was the availability of subsidized sustained release formulations for Methylphenidate, which were taken by 34% at 1 year and by 72% at 3 years. [source, 2016]
Three children were changed from dexamphetamine to Methylphenidate and four children were trialled on Atomoxetine. [source, 2016]
Measures of lean tissue, bone mineral content and bone mineral density, medication (dexamphetamine or Methylphenidate) and medication dose were not significant predictors of the rate of change of RUS score after controlling for age and sex. [source, 2016]
In separate experiments, the D1 Dopamine receptor antagonist SCH-23390 was administered five minutes before Dextroamphetamine or Atomoxetine. [source, 2015]
Time to righting was compared among the saline, Dextroamphetamine, and Atomoxetine groups using 95% confidence intervals. [source, 2015]
A Bayesian Monte Carlo procedure was used to compute 95% credible intervals to assess the effects of Dextroamphetamine and Atomoxetine on return of righting during continuous Sevoflurane general anesthesia, as described previously [13, 17, 20]. [source, 2015]