Latest research on dexlansoprazole

TAK-390MR is an investigational for the treatment of acid related disorders.. TAK-390MR employs a new modified release (MR) technology on an enantiomer of lansoprazole.

dexlansoprazole indications

The R-enantiomer is subsequently associated with decreased clearance compared to the S-enantiomer; however, this is not the sole mechanism that extends the effect of dexlansoprazole MR, as the elimination half-life of dexlansoprazole is similar to other PPIs (approximately 1–2 hours). [source, 2015]
A randomized, open-label, two-period crossover study compared the pharmacodynamic effects of single-dose dexlansoprazole MR 60 mg and esomeprazole 40 mg on 24-hour intragastric pH in healthy adult subjects. [source, 2015]
On the other hand, due to its prolonged duration of action, dexlansoprazole MR inhibits both basal and stimulated gastric acid secretion, and is effective regardless of food consumption. [source, 2015]
A recent randomized, open-label, two-period crossover study examined the effects of four different PPIs (including dexlansoprazole MR, lansoprazole, Omeprazole, and esOmeprazole) on the pharmacokinetics and pharmacodynamics of Clopidogrel. [source, 2015]
All PPIs were found to decrease the peak plasma concentration of the active metabolite of clopidogrel; however, dexlansoprazole MR was found to have the least effect. [source, 2015]
The study concluded that among PPIs, dexlansoprazole MR and lansoprazole could be selected to minimize any effect of the PPI–clopidogrel interaction.25 [source, 2015]
dexlansoprazole MR has not only been shown to be effective in providing initial symptom relief and healing of erosive esophagitis, but it has also been shown to provide continued symptom relief and Maintain endoscopic healing in patients with erosive esophagitis. [source, 2015]
dexlansoprazole MR was significantly more effective in maintaining healed erosive esophagitis than placebo. [source, 2015]
Additionally, both dexlansoprazole MR 30 mg and 60 mg were highly effective in relieving patient symptoms. [source, 2015]
A systematic review and indirect comparison of randomized controlled trials comparing the effectiveness of dexlansoprazole MR and esomeprazole in patients with NERD suggested significantly better symptom control in NERD patients treated with dexlansoprazole MR 30 mg versus esomeprazole 20 mg or 40 mg.27 [source, 2015]