Solifenacin (rINN), marketed as solifenacin succinate under the trade name Vesicare, is a urinary antispasmodic of the anticholinergic class. It is used in the treatment of overactive bladder with urge incontinence. [Wikipedia]
solifenacin succinate interactions
She was under treatment with Paroxetine and solifenacin succinate.
Under the urologist’s care, she was prescribed solifenacin succinate (5 mg/day) for 3 weeks, Oxybutynin chloride (5 mg/day) for 3 weeks, Fesoterodine fumarate (8 mg/day) for 3 months, and propiverine hydrochlroride (20 mg/day) for 4 weeks.
A fixed-dose combination (FDC) tablet of Tamsulosin oral controlled absorption system (OCAS) 0.4 mg and solifenacin succinate 6 mg (Vesomni™, Astellas Pharma Europe BV, Leiden, the Netherlands) has been recently authorized for use in men with moderate-to-severe storage symptoms and voiding symptoms associated with BPH, not adequately responding to treatment with monotherapy.
Complaining of severe symptoms, the patient had been treated with various anticholinergic agents (Cetriprin, Detrusitol, and Vesicare) with only periodical relief.
Patients in group I (n = 84) received no treatment (control group) (C group), patients in group II (n = 85) received a daily oral dose of Tamsulosin 0.4 mg (T group), patients in group III (n = 84) received solifenacin succinate 10 mg (S group), and patients in group IV (n = 85) received a combination of the two medications once daily (T/S group).
On the other hand, three new anticholinergic agents, solifenacin succinate, Tolterodine tartrate, and imidafenacin, were successively approved and marketed in recent years.
The chemical name of solifenacin succinate is 1-azabicyclo [2.2.2] octan-8-yl (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate Butanedioic acid.
At the time of her visit to our pain clinic, she was receiving Propranolol HCl 20 mg, Mirtazapine 30 mg and Tramadol HCl 50 mg twice a day, along with Buspirone HCl 15 mg, solifenacin succinate 5 mg, Mefenamic Acid 250 mg, ethyl loflazepate 1 mg and sodium tianeptine 12.5 mg daily.